Transferrin' the load
نویسندگان
چکیده
منابع مشابه
Determination of the Binding Constant of Terbium-Transferrin
Apotransferrin (apo Tf) in 0.1 M N-(2hydroxyethyl)piperazine-N2-ethanesulfanic acid at 25 ˚C and pH 7.4 has been titrated with acidic solution of Tb3+. The binding of Tb3+ at the two specific metal-binding sites of transferrin was followed from the changes in the difference UV spectra at 245 nm. The molar absorptivity per binding site for Tb3+...
متن کاملStructure of the Human Transferrin Receptor-Transferrin Complex
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of the receptor-transferrin complex. Using cr...
متن کاملMysteries of the Transferrin-Transferrin Receptor 1 Interaction Uncovered
How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells? In this issue of Cell, Cheng et al., describe the molecular structure of the human TfR1-Tf complex, This atomic model shows that Tf binds laterally to the TfR1 dimer and extends into the gap between the bottom of the receptor ectodomain and the membrane.
متن کاملTransferrin of the Hen
It is well known that in the hen the egg-white protein ovotransferrin (conalbumin) and the serum protein transferrin are very similar in structure and iron-binding properties (for review see Beam & Parker, 1966). Since it is evident that for the eggwhite protein the name 'ovotransferrin' (Komatsu & Feeney, 1967; Azari & Baugh, 1967) is more informative than the classical name 'conalbumin', it i...
متن کاملHeterotypic interactions between Transferrin Receptor and Transferrin
http://bloodjournal.hematologylibrary.org/content/101/5/2008.full.html Updated information and services can be found at: (1174 articles) Red Cells (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2005
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd1786